Petulant cellular acts: destroying the ECM rather than creating it

Petulant cellular acts: destroying the ECM rather than creating it.

What is called osteoarthritis is the most common type of joint disease in humans. This term is doubly unsatisfactory, first because it implies that a bony abnormality, consisting of subchondral dense bone and/or osteophytes, is prominent when in fact it is often absent, and second because it does not describe a single disease. Osteoarthritis is usually used to describe the clinical and patholog...

Creating and Destroying Processes

Cost Stickiness: Value Creating or Value Destroying (The Iranian Experience)

This research reviews and tests two contradicting notions in cost stickiness literature by empirical recognition of the consequences of cost stickiness. Cost stickiness is consistent with both rational resource planning and opportunistic incentives of manager to increase personal benefits arising from status and power. Although both mechanisms involve asymmetric retention of slack, some of the ...

Creating and Destroying Party Brands

Party brands are central to theories of Congressional action. While previous work assumes that a party’s brand—its long run reputation—is a direct consequence of the content of legislation, in this presentation I show how partisans from both parties use public statements to craft their own party’s reputation and to undermine their opponents party. The incentive to craft and destroy brands varie...

The half-cycle correction: banish rather than explain it.

The half-cycle correction is often used in discrete Markov models to estimate state membership. This article shows that the correction, in addition to being unintuitive, actually produces the wrong results in many circumstances. These include quality-adjusted life year (QALY) weights and unit costs that differ by cycle. The half-cycle correction is also incompatible with discounting of the obta...